How are PGT-A, PGT-SR and PGT-M performed on embryos during IVF?
The three different varieties of PGT as mentioned above all involve the same two fundamental processes. An embryo biopsy is an initial step. The second stage involves a laboratory analyzing the biopsy in order to do DNA genetic testing.
The biopsy is taken at the blastocyst stage of development (day 5 or day 6 of embryo culture) for both types of testing. The inner cell mass (ICM), which later gives rise to the infant, and trophectoderm (TE), which enables the placenta to form, are the two cell types that make up the blastocyst.
As per the doctors of Kiran Infertility Centre – Bengaluru, the biopsy involves the removal of 3–10 cells from the trophectoderm (pre-placenta) for genetic disease testing in the lab. There is no disruption of the cells that will create the baby.
Following the biopsy, results are typically available two weeks later. A cycle later, the blastocyst is thawed and transferred to the lady after being frozen immediately after being biopsied to await test results.
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